Daniel W Nebert Selected Research

Cytochrome P-450 CYP1A2 (CYP1A2)

3/2018	Cytochrome P450 1A1 (CYP1A1) protects against nonalcoholic fatty liver disease caused by Western diet containing benzo[a]pyrene in mice.
11/2016	Head-and-neck squamous cell carcinoma risk in smokers: no association detected between phenotype and AHR, CYP1A1, CYP1A2, or CYP1B1 genotype.
7/2013	Smoke carcinogens cause bone loss through the aryl hydrocarbon receptor and induction of Cyp1 enzymes.
9/2011	In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes.
1/2011	In utero and lactational exposure to a complex mixture of polychlorinated biphenyls: toxicity in pups dependent on the Cyp1a2 and Ahr genotypes.
5/2009	CYP1A1 and CYP1A2 expression: comparing 'humanized' mouse lines and wild-type mice; comparing human and mouse hepatoma-derived cell lines.
7/2006	For dioxin-induced birth defects, mouse or human CYP1A2 in maternal liver protects whereas mouse CYP1A1 and CYP1B1 are inconsequential.
5/2005	Uroporphyria and hepatic carcinogenesis induced by polychlorinated biphenyls-iron interaction: absence in the Cyp1a2(-/-) knockout mouse.
2/2005	Toward the evaluation of function in genetic variability: characterizing human SNP frequencies and establishing BAC-transgenic mice carrying the human CYP1A1_CYP1A2 locus.
2/2003	Uroporphyrin accumulation in hepatoma cells expressing human or mouse CYP1A2: relation to the role of CYP1A2 in human porphyria cutanea tarda.

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Daniel W Nebert Research Topics

Disease

28	Neoplasms (Cancer) 03/2021 - 03/2002
9	Inflammation (Inflammations) 03/2018 - 08/2009
9	Carcinogenesis 10/2013 - 08/2003
6	Necrosis 01/2019 - 03/2005
4	Atrophy 12/2015 - 05/2004
4	Body Weight (Weight, Body) 09/2014 - 11/2002
4	Hepatocellular Carcinoma (Hepatoma) 05/2009 - 05/2002
3	Coronary Artery Disease (Coronary Atherosclerosis) 01/2019 - 10/2002
3	Infections 07/2018 - 07/2006
3	Squamous Cell Carcinoma (Epidermoid Carcinoma) 09/2013 - 11/2010
3	Adenocarcinoma 09/2013 - 11/2010
3	Genetic Predisposition to Disease (Genetic Predisposition) 09/2011 - 09/2005
2	Congenital Abnormalities (Deformity) 01/2019 - 07/2006
2	Anemia 07/2018 - 01/2012
2	Drug-Related Side Effects and Adverse Reactions 07/2017 - 11/2006
2	Lung Injury 09/2014 - 02/2010
2	Atherosclerosis 02/2014 - 10/2009
2	Balkan Nephropathy (Balkan Endemic Nephropathy) 12/2012 - 10/2011
2	Liver Diseases (Liver Disease) 12/2010 - 05/2007
2	Cleft Palate (Palate, Cleft) 07/2006 - 02/2006
2	Hydronephrosis 07/2006 - 02/2006
2	Hypertrophy 04/2006 - 05/2004
2	Coronary Disease (Coronary Heart Disease) 05/2005 - 11/2002
2	Porphyria Cutanea Tarda 02/2003 - 04/2002
1	Seizures (Absence Seizure) 02/2023
1	COVID-19 12/2020
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2019
1	Parkinson Disease (Parkinson's Disease) 01/2019
1	Osteoarthritis 01/2019
1	Leigh Disease (Leigh's Disease) 01/2019
1	Hypotension (Low Blood Pressure) 01/2019
1	Hypersensitivity (Allergy) 01/2019
1	Myopia 01/2019
1	Ischemic Stroke 01/2019
1	Schizophrenia (Dementia Praecox) 01/2019
1	Systemic Lupus Erythematosus (Libman-Sacks Disease) 01/2019
1	Scoliosis 01/2019
1	Crohn Disease (Crohn's Disease) 01/2019
1	Growth Disorders 07/2018
1	Hypoxia (Hypoxemia) 07/2018
1	Non-alcoholic Fatty Liver Disease 03/2018
1	Squamous Cell Carcinoma of Head and Neck 11/2016
1	Intellectual Disability (Idiocy) 12/2015
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 12/2015
1	Fanconi Anemia (Fanconi's Anemia) 11/2015
1	Hyperoxia 09/2014

Drug/Important Bio-Agent (IBA)

19	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 03/2018 - 11/2002
14	Cytochrome P-450 CYP1A2 (CYP1A2)IBA 03/2018 - 04/2002
10	EnzymesIBA 09/2014 - 05/2004
7	Proteins (Proteins, Gene)FDA Link 03/2021 - 05/2009
7	Messenger RNA (mRNA)IBA 07/2018 - 11/2002
7	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 03/2018 - 05/2004
7	Benzo(a)pyreneIBA 03/2018 - 05/2004
6	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 07/2013 - 06/2004
6	DNA (Deoxyribonucleic Acid)IBA 12/2006 - 10/2002
5	LipidsIBA 09/2014 - 11/2002
4	Glutathione (Reduced Glutathione)IBA 02/2023 - 05/2007
4	CadmiumIBA 01/2019 - 03/2005
4	Cytochrome P450 Family 1IBA 09/2013 - 06/2004
4	Polychlorinated Dibenzodioxins (TCDD)IBA 07/2013 - 05/2004
4	DioxinsIBA 05/2009 - 11/2002
3	ManganeseIBA 12/2015 - 09/2008
3	Prostaglandins DIBA 09/2013 - 11/2010
3	aristolochic acid I (aristolochic acid)IBA 12/2012 - 10/2011
3	IronIBA 01/2012 - 04/2002
3	CarcinogensIBA 11/2010 - 08/2003
2	CationsIBA 07/2018 - 08/2009
2	SymportersIBA 07/2018 - 08/2009
2	Bile Acids and Salts (Bile Acids)IBA 03/2018 - 02/2011
2	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2014 - 02/2014
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2014 - 02/2011
2	SmokeIBA 02/2014 - 07/2013
2	Environmental Pollutants (Pollutants, Environmental)IBA 02/2014 - 12/2002
2	SerpinsIBA 10/2013 - 05/2013
2	Mixed Function Oxygenases (Monooxygenases)IBA 09/2013 - 05/2009
2	ZymosanIBA 09/2013 - 06/2008
2	Polychlorinated Biphenyls (PCBs)IBA 09/2011 - 05/2005
2	AntioxidantsIBA 12/2010 - 05/2007
2	CytokinesIBA 10/2010 - 01/2010
2	LigandsIBA 01/2010 - 05/2005
2	methoxyresorufin-O-demethylaseIBA 05/2009 - 02/2003
2	CytochromesIBA 03/2007 - 01/2005
2	Polycyclic Aromatic Hydrocarbons (Polynuclear Aromatic Hydrocarbons)IBA 04/2006 - 05/2004
2	Triglycerides (Triacylglycerol)IBA 05/2005 - 11/2002
1	Drinking WaterIBA 02/2023
1	Ascorbic Acid (Vitamin C)FDA LinkGeneric 02/2023
1	Protein Isoforms (Isoforms)IBA 03/2021
1	AerosolsIBA 12/2020
1	HDL CholesterolIBA 01/2019
1	SeleniumIBA 10/2018
1	Complement System Proteins (Complement)IBA 07/2018
1	Bicarbonates (Hydrogen Carbonate)IBA 07/2018
1	zinc-binding protein (zinc binding protein)IBA 12/2015
1	Transferrin (beta 2 Transferrin)IBA 12/2015
1	Fanconi Anemia Complementation Group ProteinsIBA 11/2015
1	Oxygen (Dioxygen)IBA 09/2014
1	Interleukin-6 (Interleukin 6)IBA 09/2014

Therapy/Procedure

5	Drug Therapy (Chemotherapy) 07/2017 - 03/2002
2	Therapeutics 07/2013 - 04/2009
1	Precision Medicine 07/2017